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KMID : 0043320140370111437
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Archives of Pharmacal Research
2014 Volume.37 No. 11 p.1437 ~ p.1444
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Optimization of ultrasonic-assisted extraction of continentalic acid from the root of Aralia continentalis by using the response surface methodology
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Kim Hyo-Seon
Lee A-Yeong
Jo Ji-Eun
Moon Byeong-Cheol
Ji Yun-Ui
Kim Ho-Kyoung
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Abstract
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In order to optimize the extraction conditions of continentalic acid, the main compound from Aralia continentalis root, we developed a model using the response surface methodology. The continentalic acid yield was analyzed and quantified by high-performance liquid chromatography coupled with UV detection. The extraction solvent, temperature, and time the three main factors for ultrasound-assisted extraction were optimized using the central composite design. Analysis of variance showed a good model fit (R2 = 0.9323). The maximum extraction of continentalic acid obtained experimentally was 1.0138 % under an extraction temperature of 33 °C and extraction time of 28 min when 100 % ethanol was used as the solvent. The experimental value was in good agreement (the yield 1.0103 %) with those predicted values. The results clearly showed that quality by statistical design could be effectively applied to optimize extraction of continentalic acid.
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KEYWORD
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Aralia continentalis, Ultrasonic-assisted extraction, Optimization, Response surface methodology, Continentalic acid
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